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That is a clinically meaningful secondary benefit for patients with type 2 diabetes, but it is not the same as the weight loss observed in obesity-specific trials at higher doses

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More specifically, the ARC nucleus of the hypothalamus has been highlighted as one of the main sites mediating this action as chemical lesion of the ARC in rats ablates the anorectic action of GLP-1 (Tang-Christensen et al., 1998)

Developed at Monash University in Australia by Professor Frank Ng during the 1990s, this peptide was specifically designed to isolate and enhance the fat-metabolizing properties of growth hormone while eliminating other systemic effects